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Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control
renale is the largest nematode to parasitize humans
In clinical trials, people taking the Wegovy pill ( semaglutide ) lost about 8% of their body weight in four months
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Conversely, GLP-1RAs increased the risk of diarrhea, hypoglycemia, vomiting, and nausea
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